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Difference Between Liquid Injection vs Lyophilized Injection



The pharmaceutical injection can be made in two forms- liquid injections and dry injection. Dry injections can be divided into two categories – lyophilized injection and dry injection.


This blog talks about the difference between liquid injections and lyophilized injections. Let’s understand the liquid injection first.


Liquid injections

  • Processing time and handling time of liquid injection are less.

  • The drug is in a liquid state.

  • There is no need for using extra sterile diluent when you reconstitute a liquid injection.

  • The manufacturing cost is comparative less as the equipment and machinery are cheaper when you make a liquid injection.

  • The manufacturing process is also simple.

  • The liquid injection is more prone to contamination. Hence, the shelf life and stability are less.

Lyophilized injections

  • Processing time and handling time of Lyophilized injection are more.

  • The drug is in solid form.

  • You need to use extra sterile diluent when you reconstitute a lyophilized injection as it is in solid form.

  • The manufacturing cost of lyophilized injection is more as it requires specialized equipment and machinery.

  • The manufacturing process is complex and time-taking.

  • Since this injection is in the solid form, it is not prone to contamination. Its shelf life and stability are better than liquid injection.

Demand for lyophilized injection is more than liquid injection. Hence, several companies are Pharma Injection Manufacturers India.


What are the benefits of lyophilized injections?

  • These injections are beneficial for patients who are in an unconscious state and unable to swallow capsulesor tablets. In such patients, it is a convenient and preferred option.

  • These injections are suitable for treating uncooperative patients.

  • Lyophilized injections are used for treating patients who don’t respond to prescribed medication.

  • The bioavailability of these injections is 100%. What does it mean? It is the degree and rate at which the administered drug gets absorbed in the body by the circulatory system. Studies indicate that lyophilized injections are easily absorbed. Hence, the body gets equipped to respond to the administered drug quickly.

  • It avoids the first-pass effect. In pharmacology, the first pass effect is a phenomenon of drug metabolism. When the concentration of a drug reduces before it reaches the circulatory system of the patient. Experiments show that the first pass effect gets comfortably avoided when these injections are administered.

Thus, the benefits of lyophilized injections are many. It is the reason behind its popularity. There has been a great increase in the production of it than the conventional liquid injections.